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An angiotensin-converting-enzyme inhibitor (ACE inhibitor) is a pharmaceutical drug used primarily for the treatment of hypertension (elevated blood pressure) and congestive heart failure. This group of drugs cause relaxation of blood vessels, as well as a decreased blood volume, which leads to lower blood pressure and decreased oxygen demand from the heart. They inhibit the angiotensin-converting enzyme, an important component of the renin-angiotensin-aldosterone system. Frequently prescribed ACE inhibitors include perindopril, captopril, enalapril, lisinopril, and ramipril. ==Medical use== ACE inhibitors were initially approved for the treatment of hypertension, and can be used alone or in combination with other antihypertensive medications. Later, they were found useful in other cardiovascular and kidney diseases including: * Acute myocardial infarction (heart attack) * Cardiac failure (left ventricular systolic dysfunction) * Kidney complications of diabetes mellitus (diabetic nephropathy) In treating heart disease, ACE inhibitors are usually used with other medications. A typical treatment plan often includes an ACE inhibitor, a beta blocker, a long-acting nitrate, and a calcium channel blocker in combinations that are adjusted to the individual patient's needs. ACE inhibitors have also been used in chronic kidney failure and kidney involvement in systemic sclerosis (hardening of tissues, as scleroderma renal crisis) 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「ACE inhibitor」の詳細全文を読む スポンサード リンク
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